How psychedelics work (for dummies)
What exactly is happening in your brain during a psychedelic experience? Let’s explore the basics.
What exactly is happening in your brain during a psychedelic experience? Let’s explore the basics.
While psychedelics have the capacity to change the future of mental healthcare, they should always be supported by proper set, setting, and integration support.
Learn more about the science behind how psychedelics work or how to create a positive set and setting for psychedelic experiences.
¹James J Gattuso, BSc, Daniel Perkins, PhD, Simon Ruffell, MBChB, PhD, Andrew J Lawrence, PhD, Daniel Hoyer, Phd, DSc, Laura H Jacobson, PhD, Christopher Timmermann, PhD, David Castle, M.D, Susan L Rossell, PhD, Luke A Downey, PhD, Broc A Pagni, PhD, Nicole L Galvão-Coelho, PhD, David Nutt, PhD, Jerome Sarris, MHSc, PhD, Default Mode Network Modulation by Psychedelics: A Systematic Review, International Journal of Neuropsychopharmacology, 2022.
²Carhart-Harris, R. L., & Goodwin, G. M. (2017). The Therapeutic Potential of Psychedelic Drugs: Past, Present, and Future. Neuropsychopharmacology, 42(11), 2105–2113.
³Carhart-Harris, Robin L., Suresh Muthukumaraswamy, Leor Roseman, Mendel Kaelen, Wouter Droog, Kevin Murphy, Enzo Tagliazucchi et al. “Neural correlates of the LSD experience revealed by multimodal neuroimaging.” Proceedings of the National Academy of Sciences 113, no. 17 (2016): 4853-4858.
⁴Petri, Giovanni, Paul Expert, Federico Turkheimer, Robin Carhart-Harris, David Nutt, Peter J. Hellyer, and Francesco Vaccarino. “Homological scaffolds of brain functional networks.” Journal of The Royal Society Interface 11, no. 101 (2014): 20140873.
⁵Carhart-Harris, R.L. & Friston, K.J. (2019). REBUS and the Anarchic Brain: Towards a Unified Model of the Brain Action of Psychedelics. Pharmacological Reviews 71, 316-344.
Psychedelics like MDMA have shown great promise in treating psychiatric disorders like PTSD. People with PTSD are often prescribed antidepressants in the selective serotonin reuptake inhibitor (SSRI) class. Individuals interested in using MDMA often ask about interactions with their antidepressants, which is an excellent question in terms of harm reduction.
Personal temperament is something rarely discussed or often overlooked when considering ingesting a psychoactive substance. Let's examine what might make an introvert's experience different on psychedelics.
Interested in implementing the healing benefits of psilocybin services into your practice? Here are Oregon training programs and other resources to get started.